What You Need to Know About Antidepressants And Weight Gain

Antidepressants and Weight Gain: What You Need to Know

Antidepressants are commonly prescribed medications that are used to treat depression, anxiety, and other related mental health conditions. While these medications can be helpful in managing mental health symptoms, they may also cause unwanted side effects, including weight gain. In this article, we’ll discuss the potential causes of antidepressant-related weight gain and provide tips on how to manage it.

Understanding Antidepressant-Related Weight Gain

Weight gain is a common side effect of taking antidepressants. It is estimated that 25-50% of people who take antidepressants will experience some degree of weight gain over the course of treatment. The amount of weight gain varies from person to person, but it is generally thought to be mild to moderate.

There are several potential mechanisms by which antidepressants can lead to weight gain. One is that the medications may cause changes in levels of hormones such as leptin, ghrelin, and cortisol. These hormones play an important role in appetite and metabolism, and can influence how much we eat and our body’s ability to burn calories. Additionally, antidepressants may increase cravings for carbohydrates and fat, leading to an increase in calorie intake.

Another potential cause of antidepressant-related weight gain is linked to the way the medications affect neurotransmitters in the brain. Antidepressants work by altering the levels of certain neurotransmitters, including serotonin and norepinephrine. These neurotransmitters are involved in many bodily processes, including appetite regulation and metabolism. Therefore, changes in their levels could contribute to weight gain.

Managing Antidepressant-Related Weight Gain

Although there is no surefire way to prevent antidepressant-related weight gain, there are several strategies that may help reduce or minimize the risk. Here are some tips for managing antidepressant-related weight gain:

  • Eat a healthy diet. Eating a balanced diet that is rich in fruits, vegetables, whole grains, lean proteins, and healthy fats can help promote healthy weight maintenance over time. Avoiding processed foods and sugary snacks can also help reduce caloric intake.
  • Stay physically active. Regular physical activity can help boost your metabolism and burn calories. Aim for at least 30 minutes of exercise each day.
  • Limit alcohol intake. Alcohol is high in calories and can contribute to weight gain when consumed in excess. Limiting your alcohol consumption may help reduce your risk for weight gain.


Antidepressants can cause unwanted side effects such as weight gain. However, there are steps you can take to manage this side effect and promote healthy weight maintenance while taking antidepressants. Eating a balanced diet and staying active are two important steps you can take to minimize your risk for weight gain related to antidepressants. If you have any questions or concerns about antidepressant-related weight gain, talk with your doctor or mental health professional for more information.