Diabetes Insipidus Causes

Diabetes Insipidus Causes

Diabetes insipidus is a rare medical condition that occurs when the body produces an abnormally large amount of urine. It is caused by a lack of antidiuretic hormone (ADH), which helps regulate the amount of water in the body. This article will discuss the five main causes of diabetes insipidus.

1. Genetic Causes

Diabetes insipidus can be caused by a genetic mutation that affects the production of ADH. In some cases, this mutation is inherited from one or both parents. In other cases, it may be triggered by an environmental factor, such as exposure to certain chemicals or drugs.

2. Traumatic Brain Injury

Traumatic brain injury (TBI) can also cause diabetes insipidus. This is because TBI can damage the hypothalamus, which is the part of the brain responsible for producing ADH. People who have had a severe head injury may experience symptoms of diabetes insipidus.

3. Autoimmune Disease

Autoimmune diseases, such as lupus and rheumatoid arthritis, can also cause diabetes insipidus. This is because these diseases cause the body to produce antibodies against its own tissues, including the hypothalamus. This can lead to an inability to produce ADH.

4. Medication Side Effects

Certain medications, such as lithium and some chemotherapy drugs, can cause diabetes insipidus as a side effect. This is because these medications interfere with the body’s ability to produce ADH.

5. Kidney Disease

Kidney diseases, such as polycystic kidney disease and chronic renal failure, can also lead to diabetes insipidus. This is because these conditions interfere with the body’s ability to reabsorb water and electrolytes, leading to an increase in urine production.


These are the five most common causes of diabetes insipidus. It is important to note that not all cases of diabetes insipidus have an identifiable cause. If you experience any symptoms of diabetes insipidus, you should talk to your doctor and get tested for this condition.